The Impacts of Estrogen and Sesame Oil on the Hippocampal Histomorphologic Changes in Mice

Masoomeh Mohammadzadeh, Fahimeh Mazaheri, Fatemeh Anbari, Mohammad Ali Khalili, ‎Department of Reproductive Biology, Reproductive Sciences Institute‎, Shahid Sadoughi University of Medical ‎Sciences, Yazd, Iran, ‎Department of Reproductive Biology, Reproductive Sciences Institute‎, Shahid Sadoughi University of Medical ‎Sciences, Yazd, Iran, ‎Department of Reproductive Biology, Reproductive Sciences Institute‎, Shahid Sadoughi University of Medical ‎Sciences, Yazd, Iran, ‎Department of Reproductive Biology, Reproductive Sciences Institute‎, Shahid Sadoughi University of Medical ‎Sciences, Yazd, Iran
2020 The Neuroscience Journal of Shefaye Khatam  
The hippocampus is one of the mos t important brain regions during adulthood, which has es trogen receptors in both genders. Since, both the es trogen and sesame have neurogenic properties, the objective of the present s tudy was to conduct the impact of es trogen and sesame oil on the hippocampal his tomorphologic changes in male mice. Materials and Methods : 20 male mice aged between 35-45 weeks were categorized into four groups: control, (received normal saline), experimental group I (sesame
more » ... oil only, 10 µl/ kg/day), experimental group II (es tradiol 1 μl/kg/day), and experimental group III (es tradiol 10 μl/kg/day). After a month, brain perfusion was done and the cerebral tissues were fixed for morphological evaluation. Results: There was a significant increase in the thickness of the dentate gyrus (DG), Cornu Ammonis 1 (CA1), and Cornu Ammonis3 (CA3) regions of all experimental groups compared to the control mice. Furthermore, there were a significant increase in the number of the granular cells and the pyramidal cells in the mice treated with sesame oil as well as es tradiol at 1 µl/kg/day. The mean number of necrosis-like cells in the CA1 and CA3 regions in the groups treated with sesame oil and es tradiol at 1 µl/kg/day was significantly lower the mice treated with 10 µl/kg/day es tradiol. Conclusion: Our data indicate that es trogen and sesame oil maintain the thickness of the CA1, CA3 and DG regions and enhance the number of the granular cells and the pyramidal cells in the hippocampal DG and CA1 areas, respectively. These findings sugges t the modulatory effects of es trogen and sesame on the hippocampal function.
doi:10.29252/shefa.8.3.29 fatcat:lepycd5rjzbuth2ojxh4th7xm4