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Drosophila cancer models to identify inhibitors that block an optimized combination of kinase targets
2012
Science-Business eXchange
Drosophila cancer models to identify inhibitors that block an optimized combination of kinase targets Screening in Drosophila cancer models could aid the identification of inhibitors against an optimized combination of kinase targets. In a Drosophila model of multiple endocrine neoplasia type 2 (MEN2), a disease caused by activating mutations in ret proto-oncogene (RET), screening a library of small molecules that inhibited RET and other kinases identified a lead molecule that caused some flies
doi:10.1038/scibx.2012.711
fatcat:daacalgfyrchrdquijgr56m4tq