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Protein Kinase C θ Inhibits Insulin Signaling by Phosphorylating IRS1 at Ser1101
2004
Journal of Biological Chemistry
Obesity and stress inhibit insulin action by activating protein kinases that enhance serine phosphorylation of IRS1 and have been thus associated to insulin resistance and the development of type II diabetes. The protein kinase C (PKC) is activated by free-fatty acids, and its activity is higher in muscle from obese diabetic patients. However, a molecular link between PKC and insulin resistance has not been defined yet. Here we show that PKC phosphorylates IRS1 at serine 1101 blocking IRS1
doi:10.1074/jbc.c400186200
pmid:15364919
fatcat:pelpdybrcbcpnc462rkubg6mme