Evaluation of Total Intravenous Anesthesia by Ketamine-Xylazine Constant Rate Infusion in Dogs: A Novel Preliminary Dose Study

Ahmed Ibrahim
2017 Veterinary Medicine - Open Journal  
and Aims: The use of ketamine-xylazine for total intravenous anesthesia (TIVA) by constant rate infusion (CRI) has not been well-documented in literature. The present study aimed to define the optimal dosage of ketamine-xylazine for TIVA in dogs and its effects on physiological body parameters. Materials and Methods: Twenty mongrel dogs were randomly assigned to four treatment protocols (n=5): A (0.5 mg kg -1 , ketamine+ 0.25 mg kg -1 , xylazine and 0.6 mg kg -1 h -1 , ketamine+0.3 mg kg -1 h
more » ... ne+0.3 mg kg -1 h -1 , xylazine ), B (5 mg kg -1 , ketamine+0.5 mg kg -1 , xylazine and 10 mg kg -1 h -1 , ket-amine+1 mg kg -1 h -1 , xylazine), C (2 mg kg -1 , ketamine+0.5 mg kg -1 xylazine and 5 mg kg -1 h -1 , ketamine+0.5 mg kg -1 h -1 xylazine), and D (2 mg kg -1 ketamine+1 mg kg -1 xylazine and 10 mg kg -1 h -1 , ketamine+1 mg kg -1 h -1 xylazine) for induction and maintenance of anesthesia, respectively. Results: The anesthesia was deep in protocols B, C, and D (pedal reflex of grade=0), but light in the protocol A (pedal reflex of grade=3). Animals in both protocols B and C showed paddling and tonic clonic convulsions. All the protocols recorded a non-significant increase in the body temperature but; a significant decrease in the respiratory rate. There was a nonsignificant decrease in the heart rate in protocols A and C; while a non-significant increase was recorded in protocols B and D. Conclusion: The protocol D could be considered as the optimal dosage of ketamine-xylazine for TIVA by CRI in dogs, with minimal effects on vital body parameters, for extended surgical interventions.
doi:10.17140/vmoj-2-114 fatcat:jztqi32ysre2bd4pwyzkib23my