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From PurUUpurU to Cytokine Storm to Hyperviscosity, Thrombosis and Other Complications of Coronavirus Disease 2019
Severe coronavirus disease 2019 (COVID-19) is associated with pathological elevations of tumor necrosis factor-alpha (TNF-ɑ) and interleukin 6 (IL-6). These cause extreme elevations of the acute phase reactant fibrinogen and plasma viscosity. Severe COVID-19 is also associated with poorly understood complications including a high incidence of arterial and venous thrombosis despite prophylactic anticoagulation, silent hypoxemia, pulmonary microvascular thrombosis, excess neutrophil extracellulardoi:10.22541/au.161372608.82975226/v1 fatcat:rqap2kbllfa4bl565lwxxc7deu