Studies of 5-aryl-4-(1H-benzo[d]imidazol-2-yl)-1-(4-(naphthalen-2-yl)thiazol-2-yl)pyrrolidin-2-one Derivatives

Kandarp H. Patel, Yogesh S. Patel
2015 Orbital: The Electronic Journal of Chemistry  
j o u r n al h o m ep ag e: w w w . o r b i t al . u f m s . b r Abstract: Novel series of heterocyclic compounds 2-aryl-1-(4-(naphthalen-2-yl)thiazol-2-yl)-5oxopyrrolidine-3-carboxylic acid derivatives (4a-h) and 5-aryl-4-(1H-benzo[d]imidazol-2-yl)-1-(4-(naphthalen-2-yl)thiazol-2-yl) pyrrolidin-2-one derivatives (5a-h) have been synthesized by condensation of Schiff bases arylidine-[4-(2-naphthalenyl)thiazolyl]-2-amines (3a-h) with succinic anhydride. Synthesized heterocyclic compounds were
more » ... c compounds were duly characterized by physico chemical parameters, 1 H-NMR, 13 C-NMR and FT-IR spectral features. Schiff bases 3a-h have been synthesized from 4-(naphthalen-2-yl)thiazol-2-amine 1 and various aromatic aldehydes 2a-h. All novel synthesized compounds 4a-h and 5a-h were evaluated for their antibacterial activity against various Gram positive bacterial strains e.g. Bacillus subtilis [BS] and Staphylococcus aureus [SA] and Gram negative bacterial strains e.g. Salmonella typhimurium [ST] and Escherichia coli [EC]. Growth inhibition was compared with the standard drug ciprofloxacin. Antifungal activity was also carried out against different fungal strains e.g. Penicillium expansum [PE], Botryodiplodia theobromae [BT], Nigrospora sp. [NS], Trichothesium sp. [TS]. The antifungal drug, Ketoconazole was used as a positive control. Compounds 4a-h found less active as compare to compound 5a-h.
doi:10.17807/orbital.v7i3.723 fatcat:ufaelu5qijfebcqbpuwidkur6i