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Syphilis remains a public health concern worldwide, the accuracy of diagnostic tests is critical for its successful control. Currently, there are two approaches to the diagnosis of syphilis using serological tests: the traditional algorithm and the reverse algorithm. The goal of this study was to analyse the advantages and disadvantages in the implementation of the syphilis reverse-screening algorithm in an outpatient clinical laboratory. An observational cross-sectional study was carried outdoi:10.4067/s0716-10182019000400525 pmid:31859779 fatcat:wfiop2vkhvehfdfuogwhs3e3l4