Complement peptide receptors (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database

Antonia Cianciulli, Liam Coulthard, Owen Hawksworth, John D. Lee, Xiang X. Li, Vincenzo Mitolo, Peter Monk, Maria A. Panaro, Trent M. Woodruff
2020 IUPHAR/BPS Guide to Pharmacology CITE  
Complement peptide receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Complement peptide receptors [103]) are activated by the endogenous ~75 amino-acid anaphylatoxin polypeptides C3a and C5a, generated upon stimulation of the complement cascade. C3a and C5a exert their functions through binding to their receptors (C3aR and C5aR), causing cell activation and triggering cellular degranulation that contributes to the local inflammation.
doi:10.2218/gtopdb/f5/2020.5 fatcat:6kmrx77rxbe4tpt46bmgqhrxbu