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INFLUENCE OF AERODYNAMIC PARTICLE SIZE ON BOTULINUM NEUROTOXIN POTENCY IN MICE
For many agents the aerodynamic particle size can affect both the virulence and disease course in animal models. Botulinum neurotoxins (BoNTs), which are widely known as potential bioterrorism agents, are toxic via multiple routes of exposure, including small particle inhalation (1-3 μm MMAD). However, the impact of larger particle sizes on the potency of BoNT has not been previously reported. Outbred mice were exposed to BoNT-containing aerosols with differing mass median aerodynamic diametersdoi:10.13016/m20pww-vedk fatcat:ewmtxb2invcytgrm6jn46hshdm