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Leptin production capacity determines food intake and susceptibility to obesity-induced diabetes in Oikawa–Nagao Diabetes-Prone and Diabetes-Resistant mice
2020
Diabetologia
Obesity caused by overeating plays a pivotal role in the development of type 2 diabetes. However, it remains poorly understood how individual meal size differences are determined before the development of obesity. Here, we investigated the underlying mechanisms in determining spontaneous food intake in newly established Oikawa-Nagao Diabetes-Prone (ON-DP) and Diabetes-Resistant (ON-DR) mice. Food intake and metabolic phenotypes of ON-DP and ON-DR mice under high-fat-diet feeding were compared
doi:10.1007/s00125-020-05191-8
pmid:32561946
fatcat:epae5ex2wbakbepa4fr2wystcm