Brain activation patterns in medicated versus medication-naïve adults with attention-deficit hyperactivity disorder during fMRI tasks of motor inhibition and cognitive switching

Jatta Berberat, Ruth Huggenberger, Margherita Montali, Philipp Gruber, Achmed Pircher, Karl-Olof Lövblad, Hanspeter E. Killer, Luca Remonda
<span title="2021-03-19">2021</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="" style="color: black;">BMC Medical Imaging</a> </i> &nbsp;
Background Adult-attention-deficit-hyperactive-disorder (ADHD) is often unrecognized condition. FMRI examination along with neuropsychological testing might strengthen the diagnosis. We hypothesized that ADHD-adults with and without medication would show different fMRI pattern compared to healthy controls while testing tasks of motor inhibition and cognitive switching. Methods 45 subjects in three age-matched groups: (1) controls, (2) ADHD-adults under medication (ADHD+) and (3)
more &raquo; ... adults with ADHD (ADHD−) underwent fMRI and neuropsychological testing. Group analysis and population-based statistics were performed. Results DTVP-A, intellectual ability as well as attention capability, visual-perceptual and visual-motor abilities showed no significant differences between the groups. However, fMRI revealed statistically significant differences between the ADHD+, ADHD− and control groups on tasks of motor inhibition and cognitive switching on adults in bilateral fronto-striatal brain regions, inferior fronto-frontal, fronto-cingulate and fronto-parietal networks as well as in the parietal lobe (p < 0.05). Conclusions fMRI offers the potential to differentiate between the ADHD+, ADHD− and control groups. FMRI possibly opens a new window for monitoring the therapeutic effect of ADHD medication. Trial registration NCT02578342, registered at August 2015 to clinical trial registry (
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="">doi:10.1186/s12880-021-00579-3</a> <a target="_blank" rel="external noopener" href="">pmid:33740903</a> <a target="_blank" rel="external noopener" href="">pmcid:PMC7977301</a> <a target="_blank" rel="external noopener" href="">fatcat:nzdyyealmrhmnjetgmg6qtmnym</a> </span>
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