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Altered Fronto-Striatal Fiber Topography and Connectivity in Obsessive-Compulsive Disorder
2014
PLoS ONE
Fronto-striatal circuits are hypothesized to be involved in the pathophysiology of obsessive-compulsive disorder (OCD). Within this circuitry, ventral frontal regions project fibers to the ventral striatum (VS) and dorsal frontal regions to the dorsal striatum. Resting state fMRI research has shown higher functional connectivity between the orbitofrontal cortex (OFC) and the dorsal part of the VS in OCD patients compared to healthy controls (HC). Therefore, we hypothesized that in OCD the OFC
doi:10.1371/journal.pone.0112075
pmid:25375933
pmcid:PMC4222976
fatcat:u63jwbc7zjha3gdmggst66q5wq