Objective: The objective of the present study was to examine the association of glucose intolerance and type-2 diabetes mellitus with the -174 G > C and -308 G > A allelic variations of IL-6 and TNF-α, respectively, through anthropometric measurements and age strata. Methods: This is a cross-sectional study using data from 285 community dwelling elderly women who underwent physical, biochemical, and genetic examinations. Results: Genotype-unadjusted analysis revealed that the risk of glucose

more »

... olerance and diabetes in elderly women with elevated BMI was 1.71 and 2.82 times higher, respectively, whereas age and conicity index did not show predictive value. Prevalence ratios for glucose intolerance and diabetes across allelic variants of IL-6 and TNF-α did not associate IL-6 with unbalanced glucose levels, despite adjustment for BMI, age, and conicity index. Conversely, carriers of the TNF-α A allele were 2.06 and 5.58 times more likely to exhibit glucose intolerance and diabetes, respectively, compared to GG homozygotes. Conclusion: Our results suggest that bearing the A allele of the -308 G > A polymorphism of TNF-α predisposes to anthropometric measure-sensitive impaired glucose metabolism in older women.