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Local higher order chromatin structure, dynamics and composition of the DNA are known to determine DSB frequencies and efficiency of repair. However, the effect of DNA damage response, vis-a-vis spatial organisation of chromosome territories is still unexplored. Our report investigates the effect of DNA damage on spatial organization of chromosome territories (CTs) within interphase nuclei of human cells. We show that DNA damage, in a dose dependent manner, induces a large-scale spatialdoi:10.1016/j.bpj.2013.11.509 fatcat:rlqgkq6anffh3e3oisg2i3utae