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Genomic information is encoded on a wide range of distance scales, ranging from tens of base pairs to megabases. We developed a multiscale framework to analyze and visualize the information content of genomic signals. Different types of signals, such as GC content or DNA methylation, are characterized by distinct patterns of signal enrichment or depletion across scales spanning several orders of magnitude. These patterns are associated with a variety of genomic annotations, including genes,doi:10.1038/nmeth.2924 pmid:24727652 pmcid:PMC4040162 fatcat:bpldem7ywveqphuwpf2af6dw7u