In vivo antioxidant activity of Moringa oleifera leaf and pod extracts against carbon tetra chloride induced liver damage in albino mice

Sharma Rakesh, Vaghela Singh
2010 J. Chem. Pharm. Res   unpublished
Study was conducted to test the hypothesis that Moringa oleifera Lam. Leave and pod has antioxidant activity. For this purpose study was designed using different concentration of crude aqueous and ethanol (alcoholic) extracts of Moringa oleifera Lam. Leaves and pods respectively to investigate protection against CCl4 induced hepatocytes injury of mice in vitro and compared with standard silymarin. Results shows that extract was effective in the reducing CCl4 induced enhanced activities of SOD,
more » ... activities of SOD, GLU, Catalase, lipid peroxidation and % viability. Data shows that CCl 4 treatment decreased SOD,catalase,glutathioe,and peroxidase while increased lipids oxidation and MDA is the by product of lipid peroxidation so increases.Pretreatment with 500 mg/kg, 750 mg/kg,1000 mg/kg(p.o.) of Moringa oleifera hydro-alcohalic leaf extract and 500 mg/kg, 750 mg/kg,1000 mg/kg(p.o.) of Moringa oleifera aqueous pods extract improved the SOD, catalase,glutathione,and peroxidase levels significantly(p>0.05) and reduced lipids peroxidationThis shows hepatocellular damage caused by CCl4 and its recovery by pretreatment with the crude extract of leaves and pods suggest that it might be considered as a potential source of natural antioxidant agent, which could be related to the free radical scavenging properties of various components present in varying concentration in the extract which is evident from the free radical measurement.