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miR-21 is involved in norepinephrine-mediated rat granulosa cell apoptosis by targeting SMAD7
2017
Journal of Molecular Endocrinology
Substantive evidence has indicated that the sympathetic innervation contributes to the regulation and development of ovarian functions. Norepinephrine (NE) is one of the major neurotransmitters contained in the extrinsic ovarian sympathetic nerves and is thought to be a potent moderator of ovarian functions such as steroidogenesis and granulosa cell proliferation or apoptosis. However, the mechanisms of NE regulation of granulosa cell apoptosis in the rat ovary are rare. Real-time PCR and
doi:10.1530/jme-16-0248
pmid:28473352
fatcat:2mk6kp2kljeutmwqtpmorilq5q