Objective-The aim of this study was to investigate whether the M235T polymorphism in the angiotensinogen gene was associated with angiotensinogen levels, systolic and diastolic blood pressure, hypertension, and risk of ischemic cardiovascular disease in different ethnic populations. Methods and Results-One hundred twenty-seven studies published between January 1992 and March 2002 examining the association of angiotensinogen gene polymorphisms with the above-mentioned end points were selected.

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... oled effect sizes and Mantel-Haenszel odds ratios were calculated using Review Manager. In white subjects, genotype was associated with a stepwise increase in plasma angiotensinogen levels of 5% (95% CI, 2% to 8%; Pϭ0.0004) in MT heterozygotes and 11% (7% to 15%; PϽ0.00001) in TT homozygotes compared with MM individuals. Correspondingly, genotype was associated with a stepwise increase in aggregated odds ratio for hypertension of 1.08 (95% CI, 1.01 to 1.15) in MT individuals and 1.19 (1.10 to 1.30) in TT individuals in white subjects and of 1.29 (95% CI, 0.96 to 1.74) and 1.60 (1.19 to 2.15) in Asian subjects. M235T genotype did not predict systolic or diastolic blood pressure or risk of ischemic heart disease or myocardial infarction in either ethnic group. Conclusions-Angiotensinogen M235T genotype was associated with a stepwise increase in angiotensinogen levels in white subjects and a corresponding increase in risk of hypertension in both white and Asian subjects. (Arterioscler Thromb Vasc Biol. 2003;23:1269-1275.) Downloaded from angiotensinogen gene, mutations, polymorphisms, systolic blood pressure, diastolic blood pressure, pulse pressure, angiotensinogen concentration, angiotensinogen levels, plasma angiotensinogen, hypertension, essential hypertension, elevated blood pressure, ischemic heart disease, coronary artery disease, myocardial infarction, ischemic cerebrovascular disease, and stroke. The following constraints were applied to the search: (1) only articles in English were used; (2) studies were only on human subjects; and (3) at least one of the polymorphisms was examined in the angiotensinogen gene: M235T, T174M, G(-6)A, or A(-20)C. Furthermore, reference lists of published studies were assessed and reviews scrutinized for missing studies. This search identified 471 articles.