There is historical evidence of link between periodontitis and rheumatoid arthritis. This associationhas been studied in 50 patients with severe periodontitis and 20 normal subjects as controls whom aged between (20-80) years at the period from to in specialized center of dental health of Babylon. The result was gave the prevalence of severe periodontitis in old patients were aged (60-80 years) 46% and female were moreeffected 60% than male 40%. According to tobacco smoking the result reveled

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... % smoking patients with periodontitis compare with non-smoking 46%, while depending on another systemic disease result was gave 38% of patients with periodontitis have diabetic mellitus, 30% with hypertension and 48% with both diseases ago. The rheumatoid arthritis result of Rheumatoid factor (RF) reveled 24% of periodontal patients were suffer from RA compare with healthy control. Hematological study erythrocyte sedimentation rate mean count show significant increasing p<0.0001 for both sex of periodontal and RA patients compare with healthy control, While immunological study for the last patients reveled high significant level P<0.0001 for IL-1β and TNF-α compare with healthy control.