Formaldehyde exposure and respiratory and related cancers. A case-referent study among Finnish woodworkers

Timo Partanen, Timo Kauppinen, Markku Nurminen, Juha Nickels, Sven Hernberg, Timo Hakulinen, ­Eero Pukkala, E Savonen
1985 Scandinavian Journal of Work, Environment and Health  
exposure and respiratory and related cancers: A case-referent study among Finnish wood work ers. Scand J Work Environ Health II (1985) 409-415. A case-referent study was undertaken to investigate the associations between formaldehyde exposure and respiratory and related cancers. Fifty-seven such cancers from a retrospective cohort of male woodworkers form ed the case group. They were mat ched by year of birth with 171 referents . Exposure to formaldehyde was assessed with job-exposure matrices
more » ... -exposure matrices . The median of the time-weighted average concentration was about I ppm, and the mean duration of exposure was 10 years among the exposed. Odds ratios (dR) were calculated for formaldehyde exposure (1.44), peak exposure to form aldehyde (1.26), and exposure to formald ehyde-containing wood dust (1.22). None of the values exceeded unity with statistical significance. Allowance was also made for a 10-year period from the onset of exposure . Birth year, cigarette smok ing and exposure to wood dust, chlorophenols, pesticides, and terpene s were contr olled by stratification . The adju sted dRs did not change appreci ably. Th e highest dR was 1.95 for formaldehyde exposure without allowance for minimum latenc y, adjusted for exposure to terpenes. No expo sure-response relation was observed for the level, duration, or dose (ppm-years) of formald ehyde exposure. Th e result is nonpositive and may be explained by absence of effect, by too short a follow-up, or by insuffici ent power for detecting a mild excess risk.
doi:10.5271/sjweh.2206 fatcat:vwys3tru2fafpkme2olgsx7ee4