Prostaglandins (PGs) are well known as one of the chemical mediators of infl ammation. Nonsteroidal anti-infl ammatory drugs (NSAIDs), PG synthesis inhibitors, are used for anti-nociception and/or anti-infl ammation. We examine the effect of loxoprofen, an NSAID, on micturiton in acetic acid-induced bladder infl ammation of the rats. In cystometrogram study with saline infusion into the urinary bladder, loxoprofen did not alter the interval of bladder contraction (IC, 107% of the control). IC

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... s shortened by acetic acid infusion (65% of the control) and loxoprofen prolonged the IC (162% of acetic acid infused period). This prolonged IC was approximately same as the control. Loxoprofen did not alter the threshold pressure and the maximal voiding pressure. These data suggest that PGE 2 might not play a part of normal micturition and may play a part of the micturition refl ex during acetic acid infusion. That is, loxoprofen might be useful for pathological hyperrefl ex of the micturition.