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Compositional Analysis of Copoly (DL-Lactic/Glycolic Acid) (PLGA) by Pyrolysis-Gas Chromatography/Mass Spectrometry Combined with One-step Thermally Assisted Hydrolysis and Methylation in the Presence of Tetramethylammonium Hydroxide

Koji URAKAMI, Atsuya HIGASHI, Kazuichi UMEMOTO, Masayuki GODO, Chuichi WATANABE, Keiji HASHIMOTO
2001 Chemical and pharmaceutical bulletin  

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Rapid and precise compositional analysis of copoly (DL-lactic/glycolic acid) (PLGA) was performed by pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS) combined with one-step hydrolysis and methylation in the presence of tetramethylammonium hydroxide (TMAH). Pyrolysis of PLGA with TMAH gave two characteristic products, derivatives of DL-lactic acid and glycolic acid, which directly reflect the average molar composition of PLGA. The analytical results for PLGA samples with various
more » ... ional ratios were in good agreement with those obtained by 1 H-NMR spectrometry, and the precision was satisfactory.
doi:10.1248/cpb.49.203 pmid:11217110 fatcat:ue6zax53ybf4dlyt7pymo6qlze
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Koji URAKAMI, Atsuya HIGASHI, Kazuichi UMEMOTO, Masayuki GODO, Chuichi WATANABE, Keiji HASHIMOTO. "Compositional Analysis of Copoly (DL-Lactic/Glycolic Acid) (PLGA) by Pyrolysis-Gas Chromatography/Mass Spectrometry Combined with One-step Thermally Assisted Hydrolysis and Methylation in the Presence of Tetramethylammonium Hydroxide." Chemical and pharmaceutical bulletin 49.2 (2001) 203-205