A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2022; you can also visit the original URL.
The file type is application/pdf
.
Monitoring extracellular ion and metabolite dynamics with recombinant nanobody-fused biosensors
[article]
2022
bioRxiv
pre-print
ABSTRACTThe tumor microenvironment (TME) consists of different cell types that secrete proteins and also control the extracellular concentration of ions and metabolites. Changes in these intra-tumoral analytes and conditions, including K+, glucose, and pH, have been described to alter the metabolic activity of cancer cells, promote tumor cell growth, and impair anti-tumor immunity. However, the mechanisms regulating ion and metabolite levels and their effects on certain characteristics of the
doi:10.1101/2022.04.12.488002
fatcat:yimm4xfk5rfmrj54ukcryiax6y