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Protein kinase A (PKA) phosphorylates and activates cAMP response element-binding protein (CREB), which then binds to CRE domain on DNA and in turn activates genes involved in the process of learning and memorization. It has been demonstrated that CREB is involve in the learning and memory deficits that are caused by ketamine. In this review, we attempt to discuss the role of ketamine and cAMP pathway and relevant regulatory protein ERK in learning and memory through the molecular mechanism andpmid:25635990 fatcat:huroejp4prhjzn6adxuifs4wsi