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Functional Significance of Prop-1 Gene Expression in Pituitary Adenomas
2000
Endocrine journal
Prophet of Pit-1(Prop-1), which is a paired-like homeodomain transcription factor, is capable of binding to sites in an early enhancer of the Pit-1 gene and regulating its expression. As human Pit-1 is expressed considerably in pituitary adenomas, we studied human Prop-1 gene expression in pituitary adenomas. We also sequenced the Prop-1 cDNAs in pituitary adenomas. Human Prop-1 transcript was detected in all pituitary adenomas examined by RT-PCR analysis. The expression of human Prop-1 in
doi:10.1507/endocrj.47.supplmarch_s85
pmid:10890192
fatcat:y5drjho32jeeriel4gvae3wbim