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Mitochondrial iPLA2Activity Modulates the Release of Cytochromecfrom Mitochondria and Influences the Permeability Transition
2006
Journal of Biological Chemistry
The mitochondrial Ca 2؉ -independent phospholipase A 2 is activated during energy-dependent Ca 2؉ accumulation under conditions where there is a sustained depression of the membrane potential. This activation is not dependent on induction of the mitochondrial permeability transition. Bromoenol lactone, which inhibits the phospholipase, is effective as an inhibitor of the transition, and this action can be overcome by low levels of exogenous free fatty acids. Apparently, activation of the Ca 2؉
doi:10.1074/jbc.m510845200
pmid:16407316
fatcat:53ghe65f5fgsfngrqcdnmosmly