The dose of the mixture does not depend on the amount of drug taken by the patient, nor on the size, weight or length of time that the patient has been under the influence of the drug. Some patients, I was informed at the Townes Hospital, are under influence of the mixture while taking from only 2 to 4 drops, the average dosage being about 12 drops, and the greatest amount administered to any patient has been 30 drops. It is impossible to state with precision the exact quantity which may cause death, belladonna with its component,