The Conquering influence of the Nano extracts of pomegranate peels and pistachio leaves in amelioration of acute liver failure [article]

Sohair Aly Hassan, Olfat Hammam, Sahar Hussein Awadallah, Wessam Magdy Aziz
2020 bioRxiv   pre-print
Objective: Acute liver failure (ALF) is a clinical condition with an unclear history of pathophysiology, making it a challenging task for scientists to reverse the disease in its initial phase and to help the liver re-function as usual: this study was proposed to estimate the hepatoprotective effects of Punica granatum peel and Pistacia atlantica leaves as a multi-rich antioxidants ingredients either in their normal and/or in their nano forms against thioacetamide induced acute liver failure in
more » ... te liver failure in a rodent model. Method: Sixty male Wistar rats were divided into six equal groups, the first group employed as a control; the second group was given a dose of thioacetamide (TAA)-350 mg/bw ip., from the third to the sixth group received TAA + 2ml of 100gm of aqueous extracts of Punica granatum L and Pistacia atlantica either in their normal and/or Nano forms consecutively along 2 weeks. Results: recorded significant elevation in liver enzymes, lipid profiles, LPO and NO with marked significant decrease in GSH and SOD accompanied by elevation in inflammatory cytokine ( IL6,TNF-α and AFP) in addition to a noticeable increase in HSP70 level & degradation in DNA respectively in TAA challenged group. However significant and subsequent amelioration of most of the impaired markers has been observed with ip nano treatment of both extracts. Conclusion: The current results highlighted the high performance of both plant nano extracts and their hepatoprotective impact and their possible therapeutic role in the amelioration of TAA induced acute liver failure in experimental animals.
doi:10.1101/2020.05.06.071001 fatcat:zweu547zczhm5ew3kuwdcdy2li