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The human and mouse genomes contain instructions that specify RNAs and proteins and govern the timing, magnitude, and cellular context of their production. To better delineate these elements, phase III of the Encyclopedia of DNA Elements (ENCODE) Project has expanded analysis of the cell and tissue repertoires of RNA transcription, chromatin structure and modification, DNA methylation, chromatin looping, and occupancy by transcription factors and RNA-binding proteins. Here we summarize thesedoi:10.1038/s41586-020-2493-4 pmid:32728249 pmcid:PMC7410828 fatcat:ozll5a2uurhbhlkuakaf4ngc24