The presence of tremor at rest, rigidity, bradykinesia, and postural instability are considered the hallmark motor features of idiopathic Parkinson's disease (IPD). These clinical features of IPD were adeptly described in 1817 by James Parkinson. The prevalence of IPD increases with age, affecting 1% of people older than 65 years of age and 2.5% of those older than 80 years. The compression of the multilayer tablet was achieved by using a single punch tablet machine. for the optimized bi-layer

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... ablet, both levodopa and carbidopa concentrations were determined using the UV-Visible Spectrophotometry method to measure the amount of released dug. The data obtained was confirmed by HPLC method. The amount of guar gum polymer in the formulation was found to affect the levodopa and carbidopa release rate significantly. A complete release of levodopa and carbidopa occurred from the bilayer tablet (A5) within 10 hours, so it was considered the optimized bilayer tablet containing the optimized amount of guar gum.