Microfluidic synthesis of monodisperse porous microspheres with size-tunable pores

Wynter J. Duncanson, Maximilian Zieringer, Olaf Wagner, James N. Wilking, Alireza Abbaspourrad, Rainer Haag, David A. Weitz
2012 Soft Matter  
We use a perfluorinated-dendrimer-dye complex that stabilizes microbubbles as a novel pore-forming agent. We use microfluidics to produce monodisperse emulsions containing a polymer matrix material, a model active, and the perfluorinated complex; upon drying, the emulsions form porous microspheres. This porosity causes the encapsulated model active to be released faster than from non-porous microspheres. Moreover, because of the fluorous features of the pores, we can also attach an additional
more » ... ach an additional guest molecule to the pores which is released with a profile that is distinct from that of the encapsulated active. These porous microspheres can encapsulate and controllably release multiple actives; this makes them valuable for applications such as drug delivery and imaging.
doi:10.1039/c2sm25694k fatcat:gfk57aqxy5fclmckyprpliok3q