Objectives: To evaluate clinical, radiological and immunohistochemichal profile of non small cell lung carcinoma (NSCLC). Settings and study design: A cross sectional study conducted among all diagnosed cases of primary lung malignancy in the Department of Respiratory Medicine MES Medical College Perinthalmanna . Materials and methods: The 41 biopsy proven cases of NSCLC was studied during a period of 1 ½ years, A detailed history, clinical evaluation and the relevant investigation is done,

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... l biopsy specimens are collected, a histopathological evaluation was done and the markers Thyroid Transcription Factor-1(TTF1), Epidermal Growth Factor Receptor (EGFR) and p-63 status was determine by immunohistochemistry(IHC) Results: Of the 41 cases, Squamous cell carcinoma was the predominant histological type with a male predominance and a peak incidence in 61-70 yrs of age. (58.53%) cases showed EGFR positivity. TTF1 positivity was predominant with adenocarcinoma and p63 positivity with squamous cell carcinoma. Smoking status and EGFR in adenocarcinoma shown that there is a significant number of EGFR positivity associated with non-smokers and all were females. The study could attain a 85.71% sensitivity and 92.59% specificity for ttf1 in adenocarcinoma and 88% sensitivity and 100% specificity for p63 in squamous cell carcinoma. Conclusion: IHC can be used as a rapid and effective tool for diagnosing the histologic type of NSCLC because of its high sensitivity and specificity. In adenocarcinoma, there is a significant number of EGFR positivity associated with nonsmokers females.