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Synthesis of some bis- and mono-2-hydroxybenzoic acid derivatives and the determination of their acidity constants
2000
Journal of the Serbian Chemical Society
Several bis-and mono-2-hydroxybenzoicacid derivatives were synthesized by thereactionofmethyl2-hydroxybenzoatewithsomealcohols(diols,polyolsandamino alcohols) and their acidity constants were determined in 60 % aqueous ethanol by the potentiometric titration method. It has been shown that the biochemical behaviour of these compounds is greatly dependent on their acidity. It appears that the ester derivativesareweakeracidsthantheamidederivativesand,therefore,canbepotentiallymore involved in the
doi:10.2298/jsc0010681d
fatcat:v4gnegylerhszhjjqlsfjvhovq