The study of the collision of heavy ions with light nuclei at low energy is important in nuclear physics, thermonuclear energy,and astrophysics. The high-precision values of the nuclear system described at an energy close to the Coulomb barrier are used to control the synthesis of light nuclei inside thermosynthesis. For cross sections of reactions of light nuclei on the sun, plasma,and stars, we can use the parameters we have set. The article presents a microscopic approach to describing the

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... ocess of nuclear-nuclear interaction.In the phenomenological approach, which determines empirical values based on comparison with experimental data, it is possible to find many sets of parameters with potentials that characterize the cross-section well. But the question arises which of them are real.Therefore, it is necessary to additionally describe microscopic potentials. For the same reason, a semi-microscopic analysis was carried out, which describes the imaginary part of the nuclear potential on the basis of an optical model, and the real part on a double-folding model.The folding potential is constructed depending on the effective nucleon-nucleon interaction based on the matrix element of two nucleons and the density of the nucleon distribution.As a result of the analysis, differential cross sections and optimal parameters were determined that well characterize the experimental cross sections of the 16О+12C nuclear system at energies ELab=20, 24, 36 MeV. The coefficients of normalization of differential cross sections, described on the basis of real microfolding potentials, were determined in the range N=0.85-1.0.