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The author has attempted in a fairly satisfactory way to give the indications and method of cocainization as an analgesic. He states as a distinctive difference between anesthesia and analgesia that "a local anesthetic of an intense frigorific character produces chemical changes, and temporarily destroys all sense, but an analgesic only affects the pain sense, and in no manner induces chemical changes, or endangers the vitality of the tissues." The book is timely and instructive. A Synopsis ofdoi:10.1001/jama.1894.02421260031017 fatcat:jp4lt3yqunehxjp4igpa3jvrzy