Pulsed Field Ablation for Pulmonary Vein Isolation in Atrial Fibrillation

Vivek Y. Reddy, Petr Neuzil, Jacob S. Koruth, Jan Petru, Moritoshi Funosako, Hubert Cochet, Lucie Sediva, Milan Chovanec, Srinivas R. Dukkipati, Pierre Jais
2019 Journal of the American College of Cardiology  
Catheter ablation of atrial fibrillation using thermal energies such as radiofrequency or cryothermy is associated with indiscriminate tissue destruction. During pulsed field ablation (PFA), subsecond electric fields create microscopic pores in cell membranes-a process called electroporation. Among cell types, cardiomyocytes have among the lowest thresholds to these fields, potentially permitting preferential myocardial ablation.
doi:10.1016/j.jacc.2019.04.021 pmid:31085321 fatcat:jrgoo36turg25kvedrztluewxu