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The aim of the present work was to study parasitological, molecular, and genetic aspects in descendants of crossbreedings between a totally resistant Biomphalaria tenagophila strain (Taim, RS) and another one highly susceptible (Joinville, SC) to Schistosoma mansoni. Descendants F 1 and F 2 were submitted to S. mansoni infection (LE strain). The susceptibility rates for individuals from Group F 1 were 0 to 0.6%, and from Group F 2 was 7.2%. The susceptible individuals from Group F 2 dischargeddoi:10.1590/s0074-02762005000100004 pmid:15867958 fatcat:jbizmiz75fgdhehdlc5f6q7v3e