Biomphalaria tenagophila: dominant character of the resistance to Schistosoma mansoni in descendants of crossbreedings between resistant (Taim, RS) and susceptible (Joinville, SC) strains

Florence Mara Rosa, Ana Lúcia Brunialti Godard, Vasco Azevedo, Paulo Marcos Zech Coelho
2005 Memórias do Instituto Oswaldo Cruz  
The aim of the present work was to study parasitological, molecular, and genetic aspects in descendants of crossbreedings between a totally resistant Biomphalaria tenagophila strain (Taim, RS) and another one highly susceptible (Joinville, SC) to Schistosoma mansoni. Descendants F 1 and F 2 were submitted to S. mansoni infection (LE strain). The susceptibility rates for individuals from Group F 1 were 0 to 0.6%, and from Group F 2 was 7.2%. The susceptible individuals from Group F 2 discharged
more » ... oup F 2 discharged a lower number of cercariae, when compared with the susceptible parental group, and in 2 out of 9 positive snails the cercarial elimination was discontinued. In order to identify genetic markers associated with resistance the genotype of parental snails and their offspring F 1 and F 2 were analyzed by means of the randomly amplified polymorphic DNA method. Nevertheless, it was not possible to detect any marker associated to resistance, but the results showed that in the mentioned species the resistance character is determined by two dominant genes.
doi:10.1590/s0074-02762005000100004 pmid:15867958 fatcat:jbizmiz75fgdhehdlc5f6q7v3e