Extracellular vesicles (EVs), including exosomes and microvesicles (MVs), have I would like to thank Marc for his time and patience, and for his infinite knowledge of science, laboratory techniques, and 80's rock. I greatly appreciate all of the support and feedback from my committee members, John Lis and Bill Brown. The Department of Molecular Medicine has been an endless source of help throughout my time at Cornell. I would especially like to thank Maurine, Debbie, Cindy, and Robin for their

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... upport. I will never forget all of the friends I have made in the Cerione laboratory, and in the BMCB program, they have made these years fun and interesting beyond measure. Finally, my husband Evan deserves my endless gratitude for being so supportive in all of our adventures together, and for making me laugh every day. v TABLE OF CONTENTS Biographical Sketch iii Acknowledgements iv Table of Contents v List of Abbreviations vi Chapter 1 Introduction 1 References 47 Chapter 2 Microvesicle Cargo and Function Changes Upon the Induction of Cellular Transformation