A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is
Identification of a gp130 Cytokine Receptor Critical Site Involved in Oncostatin M Response
Journal of Biological Chemistry
Gp130 cytokine receptor is involved in the formation of multimeric functional receptors for interleukin-6 (IL-6), IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor, and cardiotrophin-1. Cloning of the epitope recognized by an OSM-neutralizing anti-gp130 monoclonal antibody identified a portion of gp130 receptor localized in the EF loop of the cytokine binding domain. Site-directed mutagenesis of the corresponding region was carried out by alaninedoi:10.1074/jbc.275.8.5648 pmid:10681548 fatcat:oxdx5dfhqrdtvmmhvz4f5zfv3q