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KilledBacillus subtilisspores expressing streptavidin: a novel carrier of drugs to target cancer cells
2013
Journal of drug targeting (Print)
Carriers of drugs in cancer therapy are required to reduce side-effects of the drugs to normal cells. Here we constructed killed recombinant Bacillus subtilis spores (SA1) that expressed streptavidin as a chimeric fusion to the spore coat protein CotB and used the spores as bioparticle carrier. When bound with biotinylated cetuximab these spores could specifically target to the epidermal growth factor receptor on HT 29 colon cancer cells, thereby delivered paclitaxel to the cells with 4-fold
doi:10.3109/1061186x.2013.778262
pmid:23480726
fatcat:dmolnggokngarkaubzgpsj534e