Overfeeding-Induced Ovarian Dysfunction in Broiler Breeder Hens Is Associated with Lipotoxicity

S. E. Chen, J. P. McMurtry, R. L. Walzem
2006 Poultry Science  
In mammals, triacylglycerol (TAG) accumulation in nonadipose tissue, termed lipotoxicity, develops with obesity and can provoke insulin resistance, overt diabetes, and ovarian dysfunction. Leptin, an adipose tissue hormone, may mediate these effects. Feed-satiated broiler breeder hens manifest lipotoxicity-like symptoms. Changes in body and organ weights, hepatic and plasma TAG, nonesterified fatty acids (NEFA), ovarian morphology, and egg production in response to acute voluntary increases of
more » ... ntary increases of feed intake were measured in 2 studies with Cobb 500 broiler breeder hens provided with either 145 or ≥290 g of feed/d per hen for 10 d. In both studies, no hen fed 145 g of feed/d exhibited ovarian abnormalities, whereas ∼50% of feed-satiated hens did. Egg production in feed-satiated hens was reduced from 73.3 to 55.8%
doi:10.1093/ps/85.1.70 pmid:16493948 fatcat:sw4tnpjlizcxddmd4utgf7ya3u