Effects of OROS-MPH Versus Dl-Amphetamine-XR on Driving Performance of ADHD Adolescents

J Gordon Millichap
2006 Pediatric Neurology Briefs  
Caudate and anterior cingulate cortex (ACC) volumes, measured by structural MRI, were compared in children with ADHD, previously treated and untreated, and controls, in a study at the University of Texas, San Antonio and Austin; and researchers from the UK and Canada. Caudates were smaller bilaterally in both ADHD groups compared to controls. The right ACC was significantly smaller in the ADHD-treatment naive (-TN) group compared to the ADHD-treated and control groups. In contrast, the left ACC
more » ... trast, the left ACC showed no significant difference in size among the 3 groups; however, it was smaller in the ADHD-TN group compared to controls (p=0.07). Smaller left caudate volume was associated with more restlessness/impulsivity on the parent Conners scale for ADHD groups. Smaller caudates bilaterally were found in children with ADHD, and smaller caudates were associated with inattention on the Behavior Assessment Parent scale. Volume of ACC was not related to attention scores. (Pliszka SR, Lancaster J, Liotti M, Semrud-Clikeman M. Volumetric MRI differences in treatment-nai've vs chronically treated children with ADHD. Neurology
doi:10.15844/pedneurbriefs-20-10-4 fatcat:dfjdxxfanncwxith3iczkolqre