The present study was conducted to evaluate the effect of high doses of Deca-Durabolin abusing on reproductive tissue in male rats. Sixteen male rats were randomly divided into control and Deca-Durabolin group injected with 15mg/kg BW. Twice weekly for 10 weeks. Histopathological changes with Haematoxylin & Eosin stain showed the testicular lesion in the caput epididymis shows severe destruction of basement epithelial lining, with severe degeneration, necrotic and hyaline degeneration, tubules

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... ith severe loss of sperm, caput epididymal tubules cystic digestion of tubules with degeneration & necrosis of spermatid (severe destruction of epididymal parenchyma), with severe cystic distension of epididymal tubules with severe hyalinization of spermatid resulting in narrowing of tubular tissue, as well as their is proliferation interstitial of fibers connective tissue with slight cellular filtrated together with loss of spermatid in the tubules that appear empty with cystic tubular distention, the epithelial hyperplasia showing of some epididymal duct tubules that show papillary growth in the lumen together with moderate fibrosis in the interstitial tissues, although some epidermis shows empty duct with sperm degeneration, in addition to fibrous connective tissue proliferation in the interstitial tissue, variable degree of tubular destruction together with loss of spermatid and evidence of epididymal tubular distortion, different degree of tubules destruction with loss of spermatid with evidence of epididymal tubules distraction. In conclusion, the present study revealed that the abusing of Deca-Durabolin cause serious pathological changes in reproductive organs, thus affected fertility. Finally, the anabolic steroid hormone has several disadvantages should be not used androgen replacement therapy at the high dose as well as prevent using as muscle building in athletics sports.