Resting-state functional connectivity predicts recovery from visually induced motion sickness [article]

Jungo Miyazaki, Hiroki Yamamoto, Yoshikatsu Ichimura, Hiroyuki Yamashiro, Tomokazu Murase, Tetsuya Yamamoto, Masahiro Umeda, Toshihiro Higuchi
2020 bioRxiv   pre-print
Movies depicting certain types of motion often provoke uncomfortable symptoms similar to motion sickness, termed visually induced motion sickness (VIMS). VIMS generally evolves slowly during the viewing of a motion stimulus and, when the stimulus is removed, the recovery proceeds over time. Recent human neuroimaging studies have provided new insights into the neural bases underlying the evolution of VIMS. In contrast, no study has investigated the neural bases underlying the recovery from VIMS.
more » ... recovery from VIMS. Study of the recovery process is critical for the development of a way to promote recovery and could provide further clues for understanding the mechanisms of VIMS. We thus investigated brain activity during the recovery from VIMS with functional connectivity (FC) magnetic resonance imaging. We found enhanced recovery-related FC patterns involving brain areas such as the insular, cingulate, and visual cortical regions, which have been suggested to play important roles in the emergence of VIMS. These regions also constituted large interactive networks. Furthermore, the increase in FC was correlated with the subjective awareness of recovery for the following 5 pairs of brain regions: insula-superior temporal gyrus, claustrum-left and right inferior parietal lobules, claustrum-superior temporal gyrus, and superior frontal gyrus-lentiform nucleus. Considering the previous findings on the functions of these regions and the present findings, it is suggested that the increase in FC may reflect brain processes such as enhanced interoceptive awareness to one's own bodily state, a neuroplastic change in visual processing circuits, and/or the maintenance of visual spatial memory.
doi:10.1101/2020.06.30.180786 fatcat:ntjvrvsdbzew7ojazirfbu4kx4