Although Kaposi sarcoma occurs in immune compromised patients, including Human Immunodeficiency Virus (HIV) infection patients, Kaposi sarcoma associated with disseminated tuberculosis has rarely been reported on. We present a case of Kaposi sarcoma that developed in an HIV-negative patient with disseminated tuberculosis. The Kaposi sarcoma completely regressed with antituberculous therapy without the institution of any chemotherapy, radiotherapy or surgery. The patient remained disease-free after a long-term follow-up over five years.