EVALUATION OF TRIGONELLA FOENUM-GRAECUM SEEDS GUM AS A NOVEL TABLET BINDER

Research Article, Naser Tavakoli, Jaleh Varshosaz, Alireza Ghannadi, Neda Bavarsad
unpublished
A binder holds powders together to form granules and also provides the cohesiveness required for the binding of the granules under compression to form a tablet. Since Fenugreek seeds produce high viscosity mucilage at low concentration levels, the objective of the present investigation was to evaluate the binder effects of this mucilage in tableting. The mucilage of Trigonella foenum-graecum L. seed was extracted and evaluated as a tablet binder in three different model drugs in term of
more » ... in term of solubility. Calcium acetate (CA), theophylline (TH) and ibuprofen (IB) were chosen as models of freely soluble, slightly soluble and practically water insoluble, respectively. Granules containing 0.1-2.5% of the mucilage were prepared and pressed using Kilian KS single punch tableting machine. Corn starch and polyvinylpyrrolidone (PVP K30) were selected as standard binders. The physical properties of the granules (bulk density, flow-ability and granule strength) and the tablets were assessed. The results showed that a 2.5% concentration of the new binder compared well with standard binders at least for properties studied herein. At this concentration level, CA tablets showed the highest mean value in tablet hardness but prolonged disintegration times and dissolution rate. Also, the binder prolonged the disintegration time and dissolution rate of TH tablets. However, IB tablets showed the least mean value in tablet friability and moderate disintegration time-dissolution rate. The binder of Fenugreek seeds mucilage sustains the dissolution rate of water soluble drugs.
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