Modulation of APOE and SORL1 genes on hippocampal functional connectivity in healthy young adults

Junlin Shen, Wen Qin, Qiang Xu, Lixue Xu, Jiayuan Xu, Peng Zhang, Huaigui Liu, Bing Liu, Tianzi Jiang, Chunshui Yu
2017 Brain Structure and Function  
gyrus. Compared with subjects with TT genotype, SORL1 G-allele carriers had a stronger negative rsFC in APOE ε4 carriers, but a weaker negative rsFC in APOE non-ε4 carriers. These findings suggest that SORL1 and APOE genes modulate different hippocampal rsFCs and have a complex interaction. The SORL1-and APOE-dependent hippocampal connectivity changes may at least partly account for their association with AD.
doi:10.1007/s00429-017-1377-3 pmid:28229235 pmcid:PMC5541082 fatcat:jfk6qg5zsvfbfglrr7dm6fyiou