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Modulation of APOE and SORL1 genes on hippocampal functional connectivity in healthy young adults
2017
Brain Structure and Function
gyrus. Compared with subjects with TT genotype, SORL1 G-allele carriers had a stronger negative rsFC in APOE ε4 carriers, but a weaker negative rsFC in APOE non-ε4 carriers. These findings suggest that SORL1 and APOE genes modulate different hippocampal rsFCs and have a complex interaction. The SORL1-and APOE-dependent hippocampal connectivity changes may at least partly account for their association with AD.
doi:10.1007/s00429-017-1377-3
pmid:28229235
pmcid:PMC5541082
fatcat:jfk6qg5zsvfbfglrr7dm6fyiou