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Epigenetic changes are a hallmark of short-and long-term transcriptional regulation, and hence instrumental in the control of cellular identity and plasticity. Epigenetic mechanisms leading to changes in chromatin structure, accessibility for recruitment of transcriptional complexes, and interaction of enhancers and promoters all contribute to acute and chronic adaptations of cells, tissues and organs to internal and external perturbations. Similarly, the peroxisome proliferator-activateddoi:10.5451/unibas-ep88532 fatcat:n6i6a4jbsffmpoydn723zpwsh4