The potenatial roles of deubiquitinating enzymes in brain diseases

Key-Hwan Lim, Jae-Yeol Joo, Kwang-Hyun Baek
2020 Ageing Research Reviews  
Most proteins undergo posttranslational modification such as acetylation methylation, phosphorylation, biotinylation, and ubiquitination to regulate various cellular processes. Ubiquitin-targeted proteins from the ubiquitin-proteasome system (UPS) are degraded by 26S proteasome, along with this, deubiquitinating enzymes (DUBs) have specific activity against the UPS through detaching of ubiquitin on ubiquitin-targeted proteins. Balancing between protein expression and degradation through
more » ... ion through interplay between the UPS and DUBs is important to maintain cell homeostasis, and abnormal expression and elongation of proteins lead to diverse diseases such as cancer, diabetes, and auto-immune response. Therefore, development of DUB inhibitors as therapeutic targets has been challenging. In addition, understanding of the roles of DUBs in neurodegeneration, specifically brain diseases, has emerged gradually. This review highlights recent studies on the molecular mechanisms for DUBs, and discuss potential therapeutic targets for DUBs in cases of brain diseases.
doi:10.1016/j.arr.2020.101088 pmid:32470641 fatcat:htqhm7uczzdrfjo3fg3whyiovq