Although periodontitis is a chronic inflammatory disease, some factors of the acute inflammation phase are involved in this disease among which is the C-Reactive protein (CRP). CRP is one of the diagnostic markers used for the prediction and early detection of periodontal disease. Aim: The main aim was to correlate CRP level with severity of periodontitis. Materials and Methods: The present non-randomized clinical trial was carried out from June 2020 to December 2020 in the Department of

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... ntics, Saveetha Dental College and Hospitals, Chennai, India. A total of 21 patients with mild, moderate and severe periodontitis were enrolled and were divided into three groups: Group 1 -Mild periodontitis, Group 2 -Moderate periodontitis and Group 3 -Severe periodontitis with 7 patients in each group. Unstimulated salivary samples were collected and subjected to latex agglutination assay. Result: The mean level of C-Reactive protein level in mild periodontitis patients was 2.25±0.50 mg/dl, 0.56±0.78 mg/dl in moderate periodontitis patients and 4.07±0.67 mg/dl in severe periodontitis patients. We observed a positive correlation that the CRP level increases as the severity of periodontitis increases. Conclusion: The present study suggests that levels of CRP increases with severity of periodontitis. Therefore, CRP can be used as a diagnostic marker for periodontitis.